Sites and URI routes aren't tied to any particular application or directory, they are just bits of config in the overall web server configuration that map those applications to a URI to be served from.
You can make an app named "cats" and serve it from "/dogs" if you want. Go wild!
If you want to serve your Django app at the root of your domain, then use "/" as the URI endpoint.
If you want to serve your Django app from a sub-URI like "/api" or whatever, then use that and then configure your Django app uwsgi config as described here: https://help.opalstack.com/article/141/serving-a-django-app-on-a-subpath
Hope this helps! 😃
